Determining optimal therapy of dogs with chronic enteropathy by measurement of serum citrulline.

 

pubblicazione di Clinica Veterinaria San Marco | del 10/05/2018

Determining optimal therapy of dogs with chronic enteropathy by measurement of serum citrulline.

J Vet Intern Med. 2018 May;32(3):993-998. doi: 10.1111/jvim.15124. Epub 2018 Apr 16.

Determining optimal therapy of dogs with chronic enteropathy by measurement of serum citrulline.

Gerou-Ferriani M1, Allen R2, Noble PM2, German AJ2, Caldin M3, Batchelor DJ2.

Author information

Abstract

BACKGROUND:

Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states.

OBJECTIVES:

To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome.

ANIMALS:

Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease.

METHODS:

Retrospective study. Outcome was determined and dogs were categorized by response to treatment as having food-responsive enteropathy (FRE), antibiotic-responsive diarrhea (ARD), or idiopathic inflammatory bowel disease (IBD). Disease severity was quantified by the CIBDAI scoring index.

RESULTS:

Serum citrulline concentration did not differ between dogs with CE (median, 8.4 µg/mL, 5th-95th percentile 2.0-19.6) and controls (median, 8.1 µg/mL, 5th-95th percentile 2.2-19.7, P = .91). Serum citrulline concentration was similar between dogs with FRE (median, 9.1 µg/mL, 5th-95th percentile 2.0-18.9), ARD (median, 13.0 µg/mL, 5th-95th percentile 1.6-19.2), IBD (median, 8.4 µg/mL, 5th-95th percentile 2.1-21.0; P = .91). Serum citrulline did not correlate to CIBDAI or to serum albumin concentration.

CONCLUSIONS AND CLINICAL IMPORTANCE:

In our study, serum citrulline concentration was not associated with efficacy of treatment or outcome in dogs with CE.

EVENTI & NEWS in evidenza

EVENTI & NEWS in evidenza

 CONTATTI

CLINICA VETERINARIA e
 PRONTO SOCCORSO

per informazioni

  • Tel

    049 85 610 98

per appuntamenti o comunicazioni alla segreteria

LABORATORIO D'ANALISI

(riservato ai medici veterinari)

AMMINISTRAZIONE

SPORTELLO PER I MEDICI VETERINARI UTENTI DEL LABORATORIO

Vi invitiamo a utilizzare questo indirizzo anche per suggerimenti ed eventuali reclami relativi all'attività del Laboratorio

AGGIORNAMENTO PER I COLLEGHI – EVENTI SAN MARCO

 DOVE SIAMO

La Clinica/Lab Veterinaria Privata S. Marco è in Via dell'Industria 3 35030 Veggiano (Padova)

Tel. 24 h - 0498561098

Ci trovate lungo la statale Padova-Vicenza, nel comune di Veggiano (tra Mestrino e Grisignano di Zocco), a pochi chilometri dal centro di Padova e dal centro di Vicenza.
Siamo facilmente raggiungibili con l’autostrada A4, a 2Km dall’uscita di Grisignano di Zocco, in direzione Padova.

TORNA SU